Choline hydroxide
123-41-1
Definition:(2-HYDROXYETHYL)TRIMETHYLAMMONIUM HYDROXIDE;CHOLINE HYDROXIDE;CHOLINE;CHOLINE BASE;2-hydroxy-n,n,n-trimethyl-ethanaminiuhydroxide;bursine;choline,solution;fagine
Choline is a quaternary saturated amine with the chemical formula (CH3)3N+CH2CH2OHX−, where X− is a counterion such as chloride (see choline chloride), hydroxide or tartrate. Choline chloride, in mixture with urea is used as a solvent (DES) and the salicylate salt is used topically for pain relief of aphthous ulcers.
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Physiological effect:
Choline and its metabolites are needed for three main physiological purposes: structural integrity and signaling roles for cell membranes, cholinergic neurotransmission (acetylcholine synthesis), and as a major source for methyl groups via its metabolite, trimethylglycine (betaine) that participates in the S-adenosylmethionine synthesis pathways.
Apply:
1,Contribute to treatment of Alzheimer's disease
2,Treatment of nervous system diseases such as Parkinson's disease and tardive dyskinesia helpful
3,Control fat and cholesterol savings
4,Promote liver function, help the body eliminate toxins organization
5,Help send a signal to stimulate the nerve, prevent old age memory loss.
Deficiency:
Lack of long-term intake of dietary choline may include the main findings of the liver, kidney, pancreas disease, memory disorders and growth failure.
1,the liver changes: most of the animals, the lack of choline can cause liver dysfunction, a large number of liver lipid (mainly triglyceride) accumulation and eventually filled the entire liver cells.
2,kidney changes: lack also harmful to the kidneys shrink cholinergic function.
3,induced cancer: lack of choline caused by genetic damage caused by carcinogenic process first, and then some can form tumor cell survival and proliferation of variations.
4,Low-choline diet-related symptoms:infertility, growth retardation, bone abnormalities, blood disorder and hypertension were also reported.
